This study investigated the association between personality traits (i.e., anxiety sensitivity, sensation seeking, impulsivity, and hopelessness) and motives for marijuana use (i.e., enhancement of positive affect, expansion of experiential awareness, coping, social conformity, and social cohesion) in undergraduate students. It was hypothesized that anxiety sensitivity would predict coping, conformity, and social cohesion motivated use, that hopelessness would predict coping and conformity motivated use, and that impulsivity and sensation seeking would predict enhancement, expansion, and social cohesion motivated use. The sample consisted of 137 undergraduate students (110 female), with an average age of 22 years old. Anxiety sensitivity and hopelessness were found to predict coping, social cohesion, expansion, and enhancement motivated use, impulsivity was found to predict enhancement motivated use, and sensation seeking was found to predict enhancement, expansion, and social cohesion motivated use. These findings allow implications for substance use prevention and early intervention programs that address specific personality-motive patterns, to be made.